Evidence map›Paper›PMID 42061412›Full record

ArticleImmunity2026

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.

Alina Ulezko Antonova, Patrick Fernandes Rodrigues, Chelsea Mannie, Giorgia Ferrari, Horacio Carvajal, Mattia Bugatti, William Vermi, Tong Wu, Marina Cella, Pirooz Eghtesady and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Chelsea MannieDepartment of Surgery, Division of Cardiothoracic Surgery, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Giorgia FerrariDepartment of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Horacio CarvajalDepartment of Surgery, Division of Cardiothoracic Surgery, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Mattia BugattiDepartment of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.
William VermiDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA; Department of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.
Tong WuDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA.
Pirooz EghtesadyDepartment of Surgery, Division of Cardiothoracic Surgery, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA. Electronic address: eghtesady670@wustl.edu.
Marco ColonnaDepartment of Pathology and Immunology, Washington University of St. Louis School of Medicine, St. Louis, MO 63108, USA. Electronic address: mcolonna@wustl.edu.

Funding

Spontaneous and Induced B cell and T cell responses in Alzheimer's DiseaseR01AG081631 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2024 to 2026
$2.3M
NIA NIH HHS R01 AG081631
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) are innate sentinels that produce type I interferons (IFN-I) during infection. Here, we asked how developmental stage and tissue context shape human pDC transcriptional states. Single-cell RNA sequencing of pDCs from blood, thymus, lymph nodes, and tonsils across fetal, infant, and pediatric stages revealed tissue-enriched programs, including IFN-I-imprinted pDCs in the thymus, NF-κB-imprinted pDCs in tonsils, and resting pDCs in blood and lymph nodes. Across tissues, we identified a pDC subset characterized by prostaglandin D2 production and dopamine responsiveness, indicating a potential neuromodulatory axis. Cycling pDCs were abundant in fetal and infant lymphoid tissues and declined with age, while remaining enriched in bone marrow (BM) throughout life. Blastic pDC neoplasm was associated with enrichment of cycling, mutation-bearing pDCs in the BM, suggesting that this niche serves as a reservoir for malignant pDCs. Thus, early in life, pDCs are generated within various lymphoid tissues. This tissue-specific hematopoiesis may result in distinct cellular and functional outputs.

Indexed as

Dendritic CellsNeoplasmsAge FactorsBlastic Plasmacytoid Dendritic Cell NeoplasmBone MarrowChildChild, PreschoolFemaleHumansInfantInfant, NewbornInterferon Type ILymph NodesLymphoid TissueOrgan SpecificityProstaglandin D2Interferon Type IProstaglandin D2blastic plasmacytoid dendritic cell neoplasmcycling pDCsdopaminehuman tissuesplasmacytoid dendritic cellsprostaglandin D2single-cell RNA sequencingthymus

Identifiers

PMID42061412
PMCPMC13191660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.