Evidence map›Paper›PMID 42061400›Full record

ArticleCell2026

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.

Nicole E Scharping, Xuezhen Ge, Maria Inês Matias, Fulin Jiang, Allison Cafferata, Maximilian Heeg, Alexander Monell, Giovanni Galletti, Kitty P Cheung, Angelica Rock and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Nicole E ScharpingSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Xuezhen GeSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Maria Inês MatiasLa Jolla Institute for Immunology, La Jolla, CA, USA.
Fulin JiangSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Allison CafferataSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Maximilian HeegSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Alexander MonellSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Giovanni GallettiSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Kitty P CheungSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Angelica RockSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Nick ThaoSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Sydnye L ShuttleworthDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michael A BauerDepartment of Biomedical Informatics, University of Arkansas for Medical Science, Little Rock, AR, USA.
Kennidy K TakeharaSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Amir FerrySchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Sara QuonSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Brian KossDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Samuel A MyersLa Jolla Institute for Immunology, La Jolla, CA, USA.
Eric J BennettSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Ananda W GoldrathSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA; Allen Institute for Immunology, Seattle, WA, USA. Electronic address: agoldrath@ucsd.edu.

Funding

Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
Tissue-specific adaptions to promote localized T cell memoryR01AI179952 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2024 to 2026
$1.8M
Metabolic Regulation of T cell ImmunityR01AI096852 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2012 to 2015
$1.5M
Ubiquitin ligase regulation of tissue-resident T cell and anti-tumor activityR21AI178362 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2023 to 2024
$435k
NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI096852NIAID NIH HHS R01 AI179952NIAID NIH HHS R21 AI178362NIAID NIH HHS R37 AI067545NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes (TIL) often fail to restrain tumor growth due to progressive differentiation into an "exhausted" state. Tissue-resident memory T cells (T

Indexed as

Cell DifferentiationLymphocytes, Tumor-InfiltratingProteostasisAnimalsCD8-Positive T-LymphocytesHumansImmunotherapyMiceNeoplasmsProteasome Endopeptidase ComplexT-Cell ExhaustionUbiquitin-Protein LigasesProteasome Endopeptidase ComplexUbiquitin-Protein LigasescancerCD8(+) T cellE3 ubiquitin ligaseimmunotherapyproteostasisT cell exhaustiontumortumor-infiltrating lymphocyte

Identifiers

PMID42061400
PMCPMC13235417

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.