Evidence map›Paper›PMID 42061105›Full record

ArticleInternational dental journal2026

Sal-hDPSCs Transplantation Alleviates Hypoxic-Ischaemic Ferroptosis in Neonatal Rats Via the FSP1-CoQ

Kang Xu, Yan Li, Shujun Gao, Xinyue Fang, Xuan Zhang, Xueying Zhang, Fantao Wang, Xiaoli Wang

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Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kang XuDepartment of Stomatology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, China; School of Stomatology, Shandong Second Medical University, Weifang, Shandong Province, China.
Yan LiSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong Province, China.
Shujun GaoDepartment of Stomatology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, China.
Xinyue FangSchool of Stomatology, Shandong Second Medical University, Weifang, Shandong Province, China.
Xuan ZhangSchool of Stomatology, Shandong Second Medical University, Weifang, Shandong Province, China.
Xueying ZhangSchool of Stomatology, Shandong Second Medical University, Weifang, Shandong Province, China.
Fantao WangDepartment of Stomatology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, China. Electronic address: wang.fantao@163.com.
Xiaoli WangSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong Province, China. Electronic address: wxlpine@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the therapeutic effects and mechanisms of salidroside-pretreated human dental pulp stem cells (Sal-hDPSCs) on hypoxic-ischaemic brain damage (HIBD) in neonatal rats, providing a scientific basis for clinical application of hDPSCs.

methodsAn oxygen-glucose deprivation (OGD) model was established in hDPSCs. Cell viability and migration were assessed by CCK-8 and wound healing assays. The HIBD model was induced in neonatal rats using the Rice-Vannucci method and at 24 hours post-induction, hDPSCs or Sal-hDPSCs were transplanted. At 72 hours post-transplantation, cortical pathology was examined by HE and Nissl staining; Fe²⁺, malondialdehyde (MDA), superoxide dismutase (SOD) and CoQ

resultsSal pretreatment (20 μM) significantly enhanced hDPSC viability and migration after OGD. In HIBD rats, neuronal damage, elevated Fe²⁺ and MDA decreased SOD activity, reduced GPX4/FSP1 expression and CoQ

conclusionSal pretreatment enhances the survival and migratory capacity of hDPSCs under hypoxic-ischaemic conditions, thereby improving their therapeutic efficacy. Moreover, Sal-hDPSCs alleviate HIBD by inhibiting ferroptosis via the FSP1-CoQ

Indexed as

Dental PulpFerroptosisHypoxia-Ischemia, BrainStem Cell TransplantationUbiquinoneAnimalsAnimals, NewbornBlotting, WesternCell MovementCell SurvivalGlucosidesHumansPC12 CellsPhenolsRatsRats, Sprague-Dawleycoenzyme Q10GlucosidesPhenolsrhodiolosideSuperoxide DismutaseUbiquinoneFerroptosisFSP1-CoQ(10) axisHuman dental pulp stem cellsHypoxic-ischaemic brain damageNeonatal hypoxic-ischaemic encephalopathySalidroside

Identifiers

PMID42061105
PMCPMC13141575

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.