Evidence map›Paper›PMID 42061103›Full record

ReviewInternational dental journal2026

Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review.

Shahrzad Aliniay-Sharafshadehi, Mohsen Sheykhhasan, Khaled Sharifi, Ali Ansari-Mohseni, Mohammad Hasan Yousefi, Hamed Afkhami, Aida Mehdipour, Mohammad Aghaali

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shahrzad Aliniay-SharafshadehiDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
Mohsen SheykhhasanCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Khaled SharifiOrgan Transplant, Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali Ansari-MohseniDepartment of Biology, Faculty of Sciences, Islamic Azad University of Mashhad, Mashhad, Iran.
Mohammad Hasan YousefiCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran; Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
Hamed AfkhamiCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran. Electronic address: hamedafkhami70@gmail.com.
Aida MehdipourCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran. Electronic address: mehdipoor_aida@yahoo.com.
Mohammad AghaaliCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran. Electronic address: dr.aghaali@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This structured narrative review synthesises current evidence (2000-2025) on the antimicrobial, immunomodulatory, and regenerative properties of dental pulp stem cells (DPSCs) in the context of plaque-induced gingivitis and oral biofilm infections. We systematically reviewed peer-reviewed literature from PubMed, Scopus, and Web of Science via keywords related to DPSCs, oral biofilms, antimicrobial peptides (eg, β-defensins, LL-37), and immunomodulation. Unlike conventional antimicrobial therapies that solely target pathogen eradication, DPSCs offer a dual-function strategy: (1) direct microbial control through the secretion of antimicrobial peptides that disrupt Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and (2) resolution of inflammation via macrophage M2 polarisation, suppression of IL-1β/TNF-α (Interleukin-1β and Tumor Necrosis Factor-α), and microbiome rebalancing. Additionally, DPSCs support periodontal tissue regeneration through trophic signalling and differentiation into periodontal lineage cells. Critically, no clinical trials to date have evaluated DPSCs for the management of gingivitis. This review highlights DPSCs as promising, antibiotic-sparing therapeutic candidate and outlines key knowledge gaps for future translational research.

Indexed as

BiofilmsDental PlaqueDental PulpGingivitisStem CellsStem Cell TransplantationAntimicrobial PeptidesHumansPorphyromonas gingivalisAntimicrobial PeptidesAntimicrobial peptidesDental plaqueDental pulp stem cellsGingivitisOral biofilmRegenerative dentistry

Identifiers

PMID42061103
PMCPMC13140043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.