ArticlePublic health2026
Partisan differences in acetaminophen use after revised federal guidance in the United States.
Article in Public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo examine associations between partisan political identification and self-reported acetaminophen (paracetamol) use after revised federal guidance on acetaminophen issued by the current administration in September 2025. STUDY
designRepeated cross-sectional analysis of longitudinal monthly panel survey data collected from October 2025 to December 2025.
methodsRegression analysis of longitudinal survey data from the Understanding America Study (UAS), a nationally representative internet panel of over 14,000 US adults, spanning from October 2025 to December 2025. Using data on self-reported acetaminophen use and political identification over time, probability of acetaminophen use, Tylenol® use, and non-Tylenol® acetaminophen use are estimated by partisan identity (Democrat, Republican, and independent).
results43.6% of respondents reported past-month acetaminophen use. Compared to Democrats, Republicans (OR = 0.908, 95% CI 0.833-0.988) and Independents (OR = 0.821, 95% CI 0.744-0.905) had significantly lower odds of any acetaminophen use. This effect was driven primarily by Tylenol® use (Republican OR = 0.843, 95% CI 0.771-0.922; Independent OR = 0.814, 95% CI 734-.901). Republicans had significantly higher odds of using non-Tylenol® acetaminophen compared to Democrats (OR = 1.134, 95% CI 1.018-1.262).
conclusionsPartisan political identity is associated with differential patterns of acetaminophen use following revised federal guidance. Republicans reported lower Tylenol® use but higher use of other acetaminophen-containing medications, suggesting that partisan cues may shape brand-specific drug behaviour.
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