ArticleDevelopmental medicine and child neurology2026
Performance outcomes of the PEDI-CAT for assessing functional ability in the population with leukodystrophy.
Article in Developmental medicine and child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo describe the use of the Pediatric Evaluation of Disability Index-Computer Adapted Test (PEDI-CAT), a parent-reported outcome, and determine functional performance in a cohort with leukodystrophy.
methodThis was a cross-sectional observational study. Ninety-nine caregivers (of 46 females and 53 males, mean age = 7 years 11 months, age range = 2 months-34 years) completed the PEDI-CAT (Aicardi-Goutières syndrome n = 52, TUBB4A-related leukodystrophies n = 22, Pelizaeus-Merzbacher disease n = 7, POLR3-related leukodystrophy n = 18). Concurrent validity was compared between the PEDI-CAT mobility domain and the 88-item Gross Motor Function Measure (GMFM-88), and the PEDI-CAT daily activities domain with the visual motor integration (VMI) and grasping subtests of the Peabody Developmental Motor Scales, Second Edition (PDMS-2).
resultsStrong correlations were observed between the PEDI-CAT mobility domain and the GMFM-88 (Spearman's rank correlation coefficient: ρ = 0.93, 95% confidence interval [CI] = 0.90-0.95, p < 0.001), and the PEDI-CAT daily activities domain and the PDMS-2 VMI and grasping section (both Spearman's rank correlation coefficient: ρ = 0.94, 95% CI = 0.91-0.96, p < 0.001).
interpretationThe PEDI-CAT is a simple, feasible tool for caregiver assessment of function in patients with leukodystrophies; a strong correlation with established assessment tools was achieved. These findings support the use of computerized adaptive tools as a faster way to stratify functional abilities in the population with leukodystrophy.
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