Evidence map›Paper›PMID 42060824›Full record

ArticleJournal of extracellular vesicles2026

Development of CAR Exosomes Targeting FAP for the Treatment of Intrauterine Adhesion.

Wenyan Fu, Kewen Qian, Hongru Ai, Yitan Zou, Yaping Zhou, Ruixue Mao, Jian Zhao, Changhai Lei, Shi Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyan FuDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kewen QianDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Hongru AiDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Yitan ZouDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Yaping ZhouDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Ruixue MaoDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Jian ZhaoDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Changhai LeiDepartment of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Shi HuDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-8971-2391

Funding

Excellent Young Scientists Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYYQ022Interdisciplinary Research Project of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYJC202410National Natural Science Foundation of China 31970882National Natural Science Foundation of China 81773261National Natural Science Foundation of China 81903140National Natural Science Foundation of China 82041012National Natural Science Foundation of China 82322055National Natural Science Foundation of China 82421005National Natural Science Foundation of China 82473278National Natural Science Foundation of China 92169115.Shanghai Outstanding Academic Leader Program 23XD1424800Shanghai Rising-Star Program 23QA1405800The foundation of Shanghai Key Laboratory of Thoracic Tumor Biotherapy 2025SZ1004
6 · The paper itself

Abstract

Engineered extracellular vesicles (EVs) have emerged as promising cell-free platforms for immunomodulation and tissue repair. In this study, we generated EVs derived from chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) and investigated their biological and therapeutic functions. These FAP-CAR EVs effectively inhibited intrauterine fibrosis, promoted endometrial regeneration, and increased pregnancy rates in a mouse model of intrauterine adhesion. Importantly, the exosome-based therapy did not affect embryonic development or trigger systemic inflammation, indicating high safety compared with T-cell-based treatment. Mechanistically, while FAP-targeted T cells could suppress fibrosis, they also induced severe cytokine-release toxicity, which was completely avoided in the EV-based strategy. Together, these findings demonstrate that FAP is a critical target for fibrotic disease intervention and that CAR-T-derived EVs represent a safe and effective vesicle-based therapeutic modality.

Indexed as

ExosomesGelatinasesMembrane ProteinsReceptors, Chimeric AntigenSerine EndopeptidasesAnimalsDisease Models, AnimalEndopeptidasesExtracellular VesiclesFemaleFibroblast Activation Protein AlphaHumansMicePregnancyTissue AdhesionsT-LymphocytesEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsReceptors, Chimeric AntigenSerine EndopeptidasesCAR‐TexosomesFAPimmunotherapyintrauterine adhesions

Identifiers

PMID42060824
PMCPMC13132341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.