SynthesisIndian journal of pharmacology2026
Genetic and nongenetic factors affecting vancomycin population pharmacokinetics and pharmacodynamics: A systematic review.
Synthesis in Indian journal of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of adsorptive CRRT membranes on vancomycin pharmacokinetics in critically ill patients.Renal failure · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractDespite frequent vancomycin prescribing, achieving optimal therapeutic outcomes is challenging due to its complex pharmacokinetic (PK) and pharmacodynamic (PD) properties. Those characteristics are influenced by various parameters, including both genetic and non-genetic variables, rendering accurate dosing and monitoring challenging for clinicians. This systematic review was conducted in accordance with the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, ensuring a standardized and comprehensive approach to the literature search, data extraction, and reporting. We searched the publications for all appropriate evidence on genetic and non-genetic factors affecting vancomycin population PKs and PDs from 2014 to January 2024. This review's initial electronic database search found 1,543 relevant studies. Following the removal of automation-ineligible records and in-depth title relevance screening, the titles and abstracts of 67 publications were examined. After duplicate removal, 50 articles remained, and 23 were ultimately included based on the predefined inclusion and exclusion criteria. Vancomycin exhibits substantial PK and PD variability, and standard dosing often fails to achieve therapeutic targets. Area Under the Curve -guided therapeutic drug monitoring remains the most reliable strategy, while genetic factors appear to play a limited, toxicity-focused role.
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Registered trials
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