Evidence map›Paper›PMID 42060722›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Gingipain proteases from the bacterium

Carlos J Rodriguez Hernandez, Alonso Cruz-Cruz, Chandra L Shrestha, Marina Terekhova, Phylip Chen, John Perpich, Barbara Potempa, Katherine Carey, Michelle Rohlfing, Mark E Peeples and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carlos J Rodriguez HernandezCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0000-0002-9000-6427
Alonso Cruz-CruzCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0009-0008-9949-830X
Chandra L ShresthaCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.
Marina TerekhovaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Phylip ChenCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.
John PerpichDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40205.ORCID 0000-0002-7884-9202
Barbara PotempaDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40205.
Katherine CareyCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0009-0006-6415-1192
Michelle RohlfingCenter for Clinical and Translational Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0009-0007-8354-8811
Mark E PeeplesCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0000-0002-4582-317X
Mitchell H GraysonCenter for Clinical and Translational Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0000-0002-4673-2122
Jan PotempaDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40205.
Maxim ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40205.ORCID 0000-0002-3147-5039
Juhi BagaitkarCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 430205.ORCID 0000-0001-6185-1915

Funding

HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) DE031756
6 · The paper itself

Abstract

Physical interactions with bacterial colonizers at mucosal barrier surfaces can have beneficial or detrimental effects on viral infectivity and transmission. The oropharyngeal mucosal surface is a major portal of entry for many pathogenic respiratory viruses, such as respiratory syncytial virus (RSV), and also harbors a rich and diverse microbiome. Whether oropharyngeal bacteria directly or indirectly influence host susceptibility to respiratory viruses remains unknown. Here, we show that

Indexed as

Adhesins, BacterialCysteine EndopeptidasesPorphyromonas gingivalisRespiratory Syncytial Virus InfectionsRespirovirus InfectionsAnimalsFemaleGingipain Cysteine EndopeptidasesHumansInterferonsMiceRespiratory Syncytial VirusesSendai virusAdhesins, BacterialCysteine EndopeptidasesGingipain Cysteine EndopeptidasesInterferonsinterferonperiodontititsP. gingivalisRSVviral infection

Identifiers

PMID42060722
PMCPMC13142932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.