Evidence map›Paper›PMID 42060714›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis.

Mark Jung, Zhengyu Wen, Sabrina Humbert, Fengzhong Lu, Alyssa DeLeon, Lisa Marshall, Craig Hastings, Heather Cartwright, Katherine Thilges, Ning Wang and 31 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Mark JungCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0002-2312-1353
Zhengyu WenInternational Center for Maize and Wheat Improvement, Texcoco 56237, Mexico.
Sabrina HumbertCorteva Agriscience, Johnston, IA 50131.
Fengzhong LuInternational Center for Maize and Wheat Improvement, Texcoco 56237, Mexico.
Alyssa DeLeonCorteva Agriscience, Johnston, IA 50131.
Lisa MarshallCorteva Agriscience, Johnston, IA 50131.
Craig HastingsCorteva Agriscience, Johnston, IA 50131.
Heather CartwrightCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0001-6639-5808
Katherine ThilgesCorteva Agriscience, Johnston, IA 50131.
Ning WangCorteva Agriscience, Johnston, IA 50131.
Kassandra BreckenridgeCorteva Agriscience, Johnston, IA 50131.
Emily WuCorteva Agriscience, Johnston, IA 50131.
Larisa RyanCorteva Agriscience, Johnston, IA 50131.
Kevin FenglerCorteva Agriscience, Johnston, IA 50131.
Kevin SimcoxCorteva Agriscience, Johnston, IA 50131.
Shawn ThatcherCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0002-4598-8863
Victor LlacaCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0003-4822-2924
Grace WoollumsCorteva Agriscience, Johnston, IA 50131.
Jeffry SanderCorteva Agriscience, Johnston, IA 50131.
Deping XuCorteva Agriscience, Johnston, IA 50131.
Mary BeattyCorteva Agriscience, Johnston, IA 50131.
Kent BrinkCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0003-4395-9740
Maria FedorovaCorteva Agriscience, Johnston, IA 50131.
Mark JonesCorn, Soybean, and Wheat Quality Research Unit, United States Department of Agriculture-Agricultural Research Service, Wooster, OH 44691.
Erik OhlsonCorn, Soybean, and Wheat Quality Research Unit, United States Department of Agriculture-Agricultural Research Service, Wooster, OH 44691.ORCID 0000-0002-3167-2809
L M SureshInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.ORCID 0000-0001-6438-6502
Yoseph BeyeneInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.ORCID 0000-0001-7221-2617
Michael OlsenInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.
Veronica OgugoInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.
Amos AlakonyaInternational Center for Maize and Wheat Improvement, Texcoco 56237, Mexico.ORCID 0000-0001-7710-499X
Ann MurithiInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.
Stephen MugoInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.
James KaranjaKenyan Agricultural and Livestock Research Organization, Nairobi, Kenya 00200.
Prasanna BoddupalliInternational Center for Maize and Wheat Improvement, Nairobi, Kenya 00100.
Kevin PixleyInternational Center for Maize and Wheat Improvement, Texcoco 56237, Mexico.ORCID 0000-0003-4068-7436
Marc AlbertsenCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0003-3058-2366
Todd JonesCorteva Agriscience, Johnston, IA 50131.ORCID 0000-0001-5452-5601
Robert MeeleyCorteva Agriscience, Johnston, IA 50131.
Neal GuttersonCorteva Agriscience, Johnston, IA 50131.
Barbara MazurCorteva Agriscience, Johnston, IA 50131.
Kanwarpal S DhuggaInternational Center for Maize and Wheat Improvement, Texcoco 56237, Mexico.ORCID 0000-0003-2477-3422

Funding

Bill and Melinda Gates Foundation (GF) OPP1193833Gates Foundation INV-007833
6 · The paper itself

Abstract

Maize lethal necrosis (MLN) is a severe disease caused by the combined infection of maize chlorotic mottle virus (MCMV) and a potyvirus, most often sugarcane mosaic virus (SCMV). This disease seriously threatens food security across sub-Saharan Africa (SSA). We investigated a major-effect quantitative trait locus for resistance on chromosome 6, named the

Indexed as

Disease ResistancePeptide HydrolasesPeroxisomesPlant DiseasesPlant ProteinsZea maysGene Knockout TechniquesPotyvirusQuantitative Trait LociTombusviridaePeptide HydrolasesPlant Proteinsfood securitygenome editingmaize lethal necrosisperoxisomesusceptibility factor

Identifiers

PMID42060714
PMCPMC13142949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.