Evidence map›Paper›PMID 42060344›Full record

ArticleJournal of virology2026

Tylvalosin tartrate inhibits PRRSV replication by suppressing cellular pyroptosis through the TLR4/NF-κB signaling pathway.

Shi-Qin Zhang, Xin-Lei Li, Cheng Yang, Dao-Wen Li, Xiao-Hong Deng, Wei Hu, Xing-Yao Pei, Wen-Juan Zhang, Xiao-Xue Yu, Ying-Feng Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shi-Qin Zhang *College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Xin-Lei Li *College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Cheng YangCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Dao-Wen LiCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Xiao-Hong DengCollege of Veterinary Medicine, Xichang University, Xichang, China.
Wei HuCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Xing-Yao PeiCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Wen-Juan ZhangCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Xiao-Xue YuCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.ORCID 0000-0002-8570-823X
Ying-Feng SunCollege of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.ORCID 0009-0007-7130-4836

Funding

National Youth Foundation of China 32302926| Natural Science Foundation of Tianjin Municipality () 22YFZCSN00100Tianjin Municipal Human Resources and Social Security Bureau QN20230301Tianjin Municipal Human Resources and Social Security Bureau QN20230327
6 · The paper itself

Abstract

Tylvalosin tartrate, a potent antimicrobial agent, is clinically observed to mitigate porcine reproductive and respiratory syndrome virus (PRRSV) infection, yet its mechanism remains unclear. Here, we demonstrate that tylvalosin tartrate treatment significantly reduces serum viremia and inflammatory cytokine production, correlating with symptom alleviation in piglets infected with lineage 1 (L1) PRRSV.

Indexed as

Antiviral AgentsNF-kappa BPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusPyroptosisSignal TransductionToll-Like Receptor 4TylosinVirus ReplicationAnimalsCell LineMacrophages, AlveolarSwineAntiviral AgentsNF-kappa BToll-Like Receptor 4TylosintylvalosinPRRSVpyroptosisreplicationTLR4tylvalosin tartrate

Identifiers

PMID42060344
PMCPMC13289024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.