Evidence map›Paper›PMID 42060265›Full record

ArticleBioMed research international2026

Effect of a Combined Antidepressant Drug Flupentixol-Melitracen on Glucose Level and Expression of Insulin-Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.

Azizul Islam Barkat, Khandaker Asif Ahmed, Sumaiya Akter, Md Shamsudduha, Farhin Momtaz Riana, Rabeya Bosri Mehe Jabin, Mahmuda Begum, Mohammad Shamimul Alam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Azizul Islam BarkatGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0000-0002-0338-4199
Khandaker Asif AhmedCSIRO Agriculture and Food, Canberra, Australian Capital Territory, Australia, csiro.au.ORCID https://orcid.org/0000-0003-1271-7781
Sumaiya AkterGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0000-0001-7880-0823
Md ShamsudduhaGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0009-0000-8604-0510
Farhin Momtaz RianaGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0009-0007-5307-8089
Rabeya Bosri Mehe JabinGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0009-0001-5569-7779
Mahmuda BegumZoology Section, Biological Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-0908-5680
Mohammad Shamimul AlamGenetics and Molecular Biology Laboratory, Department of Zoology, University of Dhaka, Dhaka, Bangladesh, du.ac.bd.ORCID https://orcid.org/0000-0002-4430-1097

Funding

Ministry of Science and Technology, Government of the People's Republic of BangladeshUniversity Grants Commission of Bangladesh 2020-21
6 · The paper itself

Abstract

The number of depression sufferers is increasing at an alarming rate around the world. As a result, the usage of antidepressant drugs is growing day by day. However, the effect of this medication on glucose homeostasis is not clear. We investigated the impact of a combined antidepressant drug flupentixol-melitracen on glucose levels and the expression of associated genes in Drosophila melanogaster. The flies were reared in control and treatment vials having standard and drug-treated food. The glucose oxidase method showed significantly reduced glucose levels in the treated Drosophila. The Ct values obtained from qPCR for the relative quantification of Drosophila insulin-like peptide (DILP) genes, DILP5 and DILP6, were analyzed using the 2

Indexed as

Antidepressive AgentsDrosophila melanogasterDrosophila ProteinsFlupenthixolGlucoseInsulin-Like PeptidesAnimalsGene Expression RegulationInsulinInsulinsSignal TransductionAntidepressive AgentsDrosophila ProteinsFlupenthixolGlucoseIlp5 protein, DrosophilaInsulinInsulin-Like PeptidesInsulinsbioinformaticsdepressionfrenxitinsulinLC50

Identifiers

PMID42060265
PMCPMC13131322

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.