ArticleJournal of assisted reproduction and genetics2026
Use of low versus high oxygen tension during pre-maturation only in capacitation in vitro maturation (CAPA-IVM): impact on oocyte maturation and metabolism.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo determine the impact of low versus atmospheric oxygen tension during only the pre-maturation phase of biphasic capacitation in vitro maturation.
methodsThe study involved sibling oocytes (532 cumulus-oocyte complexes [COCs] from 20 participants [mean age 29.5 ± 2.5 years]) with polycystic ovary syndrome undergoing CAPA-IVM without gonadotrophins. After oocyte pick-up (OPU), COCs were randomized to undergo pre-maturation under low or atmospheric oxygen, then IVM culture at 20% oxygen. The primary outcome was the oocyte maturation rate. Secondary outcomes included rates of fertilization, blastulation, and good-quality blastocysts. Cumulus cell gene expression was also determined, and glucose and lactate concentrations in spent culture media were analyzed.
resultsOocyte maturation rates per COC (59.8% vs. 56.1%; p = 0.47) and per patient (61% vs. 55%; p = 0.34) were comparable between the atmospheric vs. low oxygen groups. Fertilization rates were significantly higher in the atmospheric versus low oxygen group; all other embryology outcomes were similar between groups. Significantly different cumulus cell gene expression was seen for LDHA (glucose metabolism; lower in the low oxygen group), CPT1A (lipid shuttle; higher in the low oxygen group), and NDRG1 (hypoxia response; lower in the low oxygen group). Glucose consumption and lactate production were comparable between groups during pre-maturation, but lower in the low oxygen group during IVM.
conclusionsOverall, although low oxygen tension during CAPA-IVM pre-maturation reduces the number of fertilized oocytes, it does not compromise fertilized oocyte quality or embryological outcomes.
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