Evidence map›Paper›PMID 42060163›Full record

Observational studyAdvances in therapy2026

Coexisting Type 2 Inflammatory Conditions in Patients with Asthma Treated with Dupilumab: the RAPID Registry.

Anju T Peters, Andréanne Côté, Xavier Muñoz, Changming Xia, Scott Nash, Megan Hardin, Lucía de Prado Gómez, Harry J Sacks, Juby A Jacob-Nara, Paul J Rowe and 1 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04287621 (Registry of Asthma Patients Initiating DUPIXENT®), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04287621 completednot on this map

Registry of Asthma Patients Initiating DUPIXENT® (RAPID)

Typeobservational_patient_registrySponsorRegeneron PharmaceuticalsRan2020 to 2026Enrolled718ConditionsAsthmaArmsDUPIXENT®
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anju T PetersAllergy-Immunology Division and the Sinus and Allergy Center, Northwestern University Feinberg School of Medicine, 211 E Ontario St, Suite 1000, Chicago, IL, 60611, USA. anjupeters@northwestern.edu.ORCID http://orcid.org/0000-0003-0745-2379
Andréanne CôtéQuebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada.
Xavier MuñozHospital Vall d'Hebron, Barcelona, Spain.
Changming XiaRegeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Scott NashRegeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Megan HardinSanofi, Cambridge, MA, USA.
Lucía de Prado GómezSanofi, Madrid, Spain.
Harry J SacksRegeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Juby A Jacob-NaraSanofi, Morristown, NJ, USA.
Paul J RoweSanofi, Morristown, NJ, USA.
Yamo DenizRegeneron Pharmaceuticals Inc., Tarrytown, NY, USA.

Funding

Regeneron Pharmaceuticals NCT04287621Sanofi NCT04287621
6 · The paper itself

Abstract

introductionCoexisting type 2 inflammatory diseases such as allergic rhinitis (AR), atopic dermatitis (AD), chronic rhinosinusitis (CRS) and/or nasal polyposis (NP), eosinophilic esophagitis (EoE), and urticaria are common in asthma. RAPID (NCT04287621), a global prospective registry, aimed to characterize patients with asthma initiating dupilumab in a real-world clinical setting. This analysis investigated the prevalence of coexisting type 2 inflammatory diseases in these patients.

methodsPatients aged ≥ 12 years initiating dupilumab for asthma (primary indication) according to country-specific prescribing information were enrolled in RAPID. Patients had regular assessments at 1 month and thereafter every 3 months for up to 3 years, per standard of care across study sites.

resultsAt the time of analysis, 205 patients were enrolled. Mean age of patients (stratified by type 2 coexisting disease) ranged from 42.3 to 57.3 years and mean body mass index from 29.9 to 31.8 kg/m

conclusionThis analysis from the RAPID registry shows that type 2 coexisting diseases are highly prevalent in patients with asthma initiating dupilumab in a clinical practice setting and highlights the importance of properly assessing patients to improve patient care.

trial registrationClinicalTrials.gov: NCT04287621.

Indexed as

Antibodies, Monoclonal, HumanizedAsthmaAdolescentAdultDermatitis, AtopicEosinophilic EsophagitisFemaleHumansMaleMiddle AgedNasal PolypsProspective StudiesRegistriesRhinitis, AllergicRhinosinusitisUrticariaAntibodies, Monoclonal, HumanizeddupilumabAllergic rhinitisAsthmaAtopic dermatitisCoexisting type 2 inflammatory diseaseCRS and/or NPDupilumabEoEReal-worldRegistryUrticaria

Identifiers

PMID42060163
PMCPMC13290785

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.