Evidence map›Paper›PMID 42060152›Full record

ArticleEJNMMI radiopharmacy and chemistry2026

Radiation stability and performance of TEHDGA resin for theranostic scandium radionuclide purification.

Rudolfs Janis Zabolockis, Edgars Mamis, Laura Dace Pakalniete, Liga Avotina, Maris Bertins, Janis Sadauskis, Aina Semjonova, Jarosław Sadło, Magdalena Rzepna, Jevgenijs Proskurins and 1 more

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In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rudolfs Janis ZabolockisFaculty of Science and Technology, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Edgars MamisFaculty of Science and Technology, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Laura Dace PakalnieteFaculty of Science and Technology, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Liga AvotinaFaculty of Science and Technology, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Maris BertinsFaculty of Medicine and Life Sciences, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Janis SadauskisFaculty of Medicine and Life Sciences, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Aina SemjonovaFaculty of Medicine and Life Sciences, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia.
Jarosław SadłoInstitute of Nuclear Chemistry and Technology, Instytut Chemii i Techniki Jądrowej), 16 Dorodna str, Warszawa, 03-195, Poland.
Magdalena RzepnaInstitute of Nuclear Chemistry and Technology, Instytut Chemii i Techniki Jądrowej), 16 Dorodna str, Warszawa, 03-195, Poland.
Jevgenijs ProskurinsFaculty of Medicine, Riga Stradins University, Anninmuizas blvd. 26A, Riga, LV-1067, Latvia.
Elina PajusteFaculty of Science and Technology, University of Latvia, 1 Jelgavas str, Riga, LV-1004, Latvia. elina.pajuste@lu.lv.ORCID http://orcid.org/0000-0003-1036-4679

Funding

Latvijas Zinātnes Padome lzp-2021/1-0539
6 · The paper itself

Abstract

backgroundScandium radionuclides are emerging theranostic radionuclides that offer matched diagnostic and therapeutic emissions for targeted applications in nuclear medicine. For their safe and effective clinical use, it is crucial to obtain preparations with very high radiochemical purity, which in turn relies on carefully optimized physical separation and chemical purification strategies. A selective and clinically attractive method for purification is ion-exchange solid-phase extraction; however, its performance and expected resin lifetime under high radiation doses and repeated separation cycles remains insufficiently considered. This study provides a critical evaluation of the radiation stability and separation performance of the N, N,N',N'-tetra(2-ethylhexyl)diglycolamide (TEHDGA) ion-exchange resin.

resultsMonte Carlo simulations in RayXpert

conclusionsTEHDGA resin can be deemed suitable for theranostic scandium radionuclide purification from metallic contaminants; however, further research is needed to assess the possible transient effects of short-lived radiolysis intermediates during practical scandium radionuclide purification.

Indexed as

Diglycolamide ion-exchange resinsRadiation stabilityScandium radionuclideTEHDGATheranostics

Identifiers

PMID42060152
PMCPMC13275935

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.