Evidence map›Paper›PMID 42060134›Full record

SynthesisCalcified tissue international2026

Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.

Mustafa Guldan, Lasin Ozbek, Derya G Fidan, Arif E Narin, Ditte Hansen, Juan M Diaz-Tocados, Mathias Haarhaus, Martin H de Borst, Carlo Alfieri, Pietro M Ferraro and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mustafa GuldanSchool of Medicine, Koç University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-0480-5370
Lasin OzbekSchool of Medicine, Koç University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-2828-555X
Derya G FidanSchool of Medicine, Koç University, Istanbul, Turkey.ORCID http://orcid.org/0009-0000-6686-9604
Arif E NarinSchool of Medicine, Koç University, Istanbul, Turkey.
Ditte HansenDepartment of Nephrology, Copenhagen University Hospital - Herlev, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4929-7901
Juan M Diaz-TocadosVascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.ORCID http://orcid.org/0000-0001-5192-5212
Mathias HaarhausDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8274-6356
Martin H de BorstDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
Carlo AlfieriNephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan, 20122, Milan, Italy.ORCID http://orcid.org/0000-0003-3860-5219
Pietro M FerraroSection of Nephrology, Department of Medicine, Università degli Studi di Verona and Nephrology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Antonio BellasiService of Nephrology, Ospedale Regionale di Lugano, Ospedale Civico, Ente Ospedaliero Cantonale, Lugano, Switzerland.ORCID http://orcid.org/0000-0001-7830-1645
Mehmet KanbayDivision of Nephrology, Department of Internal Medicine, School of Medicine, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey. mkanbay@ku.edu.tr.ORCID http://orcid.org/0000-0002-1297-0675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although α-Klotho has gained attention as a promising biomarker of aging, its association with frailty and broader aging-related outcomes beyond chronic kidney disease-mineral and bone disorder remains incompletely characterized. This systematic review and meta-analysis aimed to investigate the association between circulating α-Klotho levels and aging-related outcomes, including frailty, effects of physical activity and exercise interventions, body composition, cognitive and neuropsychiatric status, sarcopenia, and bone mineral density (BMD). A comprehensive literature search was performed across multiple electronic databases, including Ovid MEDLINE, Web of Science, Scopus, PubMed, and the Cochrane Library, to identify relevant studies published up to April 30, 2025. Pooled analyses were conducted using random-effects models, with effect estimates synthesized as mean differences, odds ratios, or correlation coefficients, and heterogeneity assessed using the I

Indexed as

AgingChronic Kidney Disease-Mineral and Bone DisorderFrailtyGlucuronidaseKlotho ProteinsBiomarkersBone DensityExerciseHumansBiomarkersGlucuronidaseKlotho ProteinsKL protein, humanBody compositionExercise trainingFractureFrailtyKlothoPhysical activity

Identifiers

PMID42060134
PMCPMC13132909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.