Evidence map›Paper›PMID 42060122›Full record

ReviewCalcified tissue international2026

The Role of Plastin in Bone, Cartilage, and Related Diseases.

Zuping Wu, Hengyuan Liu, Ruifeng Song, Siyu Chen, Jiejun Shi, Xiaoxia Feng, Qian Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zuping Wu *Stomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China.ORCID http://orcid.org/0000-0003-3661-8593
Hengyuan Liu *Stomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Ruifeng SongStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Siyu ChenStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Jiejun ShiStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Xiaoxia FengStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China. 0014725@zju.edu.cn.
Qian ChenStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, 310016, China. 7322045@zju.edu.cn.

Funding

National Natural Science Foundation of China 82501200the National Natural Science Foundation 82401098
6 · The paper itself

Abstract

The plastin family (PLS1, PLS2, PLS3) comprises highly conserved actin-binding proteins (ABPs) that regulate cytoskeletal dynamics by cross-linking actin microfilaments and play key roles in bone and cartilage development, homeostasis, and disease. PLS1 primarily stabilizes tight actin bundles in epithelial brush-border microvilli and has also been reported to support osteoblast differentiation via regulating intracellular Ca2+ homeostasis. In bone, PLS3 mutations lead to X-linked osteoporosis through mechanisms involving the inhibition of the WNT pathway, activation of TH17 cell differentiation, and disorders of osteogenesis mediated by the neutrophil extracellular trap (NET) pathway. Meanwhile, PLS2 promotes osteoclast sealing ring assembly and drives bone resorption via Ser-5/Ser-7 phosphorylation. In cartilage, PLS3 is highly expressed on the surface layer of osteoarthritis (OA) patients, with expression levels positively correlating with degeneration severity, possibly involved in chondrocyte hypertrophy in response to mechanical loading. Pathologically, PLS3 deficiency directly causes early-onset osteoporosis and increased fracture risk, while PLS2 plays a dual role in cancer metastasis and inflammation. Targeting plastin, such as inhibiting PLS2 phosphorylation or supplementing PLS3 mRNA, offers potential new strategies for treating hyperresorption and hereditary bone diseases.

Indexed as

Bone and BonesBone DiseasesCartilageCartilage DiseasesMembrane GlycoproteinsMicrofilament ProteinsAnimalsHumansMembrane GlycoproteinsMicrofilament ProteinsplastinActin-binding proteinOsteoarthritisOsteoblastOsteoclastOsteoporosisPlastin

Identifiers

PMID42060122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.