Evidence map›Paper›PMID 42060042›Full record

ArticleInternal and emergency medicine2026

Burden, features and factor associated with disorders of gut-brain axis in Italy: results from the Rome foundation global epidemiology study.

Giovanni Marasco, Keren Hod, Luigi Colecchia, Cesare Cremon, Enrico Stefano Corazziari, Ami David Sperber, Olafur Steinn Palsson, Shrikant Ishver Bangdiwala, Giovanni Barbara

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In one paragraph

Article in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giovanni Marasco *Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.
Keren Hod *Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Luigi Colecchia *Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.
Cesare CremonIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Enrico Stefano CorazziariCentro di Eccellenza di Malattie Gastrointestinali ed Endocrino-Metaboliche, Ospedale Isola Tiberina, Rome, Italy.
Ami David SperberFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Olafur Steinn PalssonCenter for Functional GI and Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Shrikant Ishver BangdiwalaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Giovanni BarbaraDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy. giovanni.barbara@unibo.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of gut-brain interaction (DGBI) are prevalent and burdensome conditions. This study aimed to assess the prevalence, regional distribution, and associated factors of DGBI in Italy, and compare findings with the rest of Europe. Data were drawn from the Rome Foundation Global Epidemiology Study. A representative sample of 2063 Italian adults completed a internet-based questionnaire assessing DGBI presence, psychological distress, somatic symptoms, dietary habits, and healthcare utilization. Comparative analysis was conducted within the country and with other European countries. Multivariate logistic regression identified independent associated factors in Italy. Overall, 44.2% of Italian participants met criteria for at least one DGBI with higher prevalence in women and individuals aged 18-39 years. The South and Islands showed the highest DGBI prevalence. Functional constipation (13.9%) and functional dyspepsia (9.1%) were the most common DGBI, while irritable bowel syndrome affected 5.0% of the population. Psychological distress, somatic symptom burden, female sex, and younger age were independently associated with DGBI, while living in small rural communities showed an inverse association. Compared to the rest of Europe, Italy showed higher DGBI rates across multiple gastrointestinal regions and more frequent overlapping DGBI. DGBI represent a substantial burden in Italy compared with the rest of Europe, with marked regional and psychosocial gradients.

Indexed as

Brain-Gut AxisGastrointestinal DiseasesAdolescentAdultAgedDyspepsiaFemaleHumansIrritable Bowel SyndromeItalyLogistic ModelsMaleMiddle AgedPrevalenceSurveys and QuestionnairesYoung AdultDisorders of gut–brain interactionFunctional dyspepsiaIrritable bowel syndromeItaly

Identifiers

PMID42060042
PMCPMC13452765

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.