How Medically Important Antimicrobials Bind to the 30S Ribosomal Subunit in a Bacterial Pathogen.

Swati R Manjari, Caleb Mallery, Nilesh K Banavali

Abstract read

In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Ribosome hibernation in zinc-starvedMicrobiology spectrum · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Swati R ManjariLaboratory of Cellular and Molecular Basis of Diseases, Division of Genetics, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12237, United States.

Caleb MalleryDepartment of Biomedical Sciences, College of Integrated Health Sciences, Pine Bush Building, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.

Nilesh K BanavaliLaboratory of Cellular and Molecular Basis of Diseases, Division of Genetics, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12237, United States.ORCID 0000-0003-2206-7049

Funding

Role of Protein Tyrosine Phosphatase 1B in Cardiac HypertrophyR01HL175391 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Benoit Boivin · 2024 to 2026

$1.6M

NHLBI NIH HHS R01 HL175391

6 · The paper itself

Abstract

Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions near the decoding center are a target for antibiotics, such as aminoglycosides and tetracyclines, where their presence results in errors in protein synthesis. More than two decades of high-resolution structural studies have shown how such medically important antimicrobials (MIAs) bind to the small subunit of the bacterial ribosome. Here, we comprehensively analyze these previously reported structures to help understand the variability with which MIAs bind to small subunits of bacterial ribosomes. We previously solved the hibernating 70S ribosome structure of the bacterial pathogen

Indexed as

Anti-Bacterial AgentsBorrelia burgdorferiRibosome Subunits, Small, BacterialModels, MolecularProtein BindingAnti-Bacterial Agents

Identifiers

PMID42059878

DOI10.1021/acs.biochem.6c00008

PMCPMC13210265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.