Evidence map›Paper›PMID 42059867›Full record

ArticleThe Journal of cell biology2026

Regulation of the Cell Wall Integrity pathway at the contact site between mating partners in yeast.

Erin R Curtis, Aarshi Jain, Daniel J Lew

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Erin R CurtisBiology Department, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1914-9847
Aarshi JainBiology Department, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1764-7236
Daniel J LewBiology Department, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7482-3585

Funding

Studies on cell polarity, chemotropism, and cell cycle controlR35GM122488 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANIEL J LEW · 2017 to 2026
$6.9M
National Institutes of Health/National Institute of General Medical Sciences R35GM122488NIGMS NIH HHS R35 GM122488
6 · The paper itself

Abstract

The fungal cell wall is constantly remodeled to allow cell growth, but any holes in the cell wall would lead to catastrophic lysis. The "Cell Wall Integrity" pathway (CWI) detects cell wall defects and promotes cell wall thickening or repair to protect cell integrity. However, cell walls must be removed at contact sites between fusing cells during mating or mycelium formation. Here, we show that in Saccharomyces cerevisiae, the CWI is downregulated specifically at the contact site between mating cells. A key component of the CWI, Pkc1, accumulated at polarity sites (shmoo tips) in cells exposed to mating pheromone, but not at contact sites. Pkc1 exclusion required a cell wall protein, Fig2, induced by pheromone. In mutants lacking Fig2, cell wall removal was delayed, blocked, or even reversed after transient fusion, leading to reduced mating. These results suggest that Fig2 designates the contact site as a "safe" spot to degrade the cell wall.

Indexed as

Cell WallSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell PolarityGene Expression Regulation, FungalPheromonesProtein Kinase CSignal TransductionPheromonesPKC1 protein, S cerevisiaeProtein Kinase CSaccharomyces cerevisiae Proteins

Identifiers

PMID42059867
PMCPMC13286567

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.