Evidence map›Paper›PMID 42059844›Full record

ArticleJACC. Advances2026

Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women.

Thara S Ali, Roberta M diFlorio-Alexander, Judith A Austin-Strohbehn, Thomas S Truglio, Emily P Zeitler, Hemant Kulkarni, Amit P Amin, Cynthia C Taub

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thara S AliNorthwell, New Hyde Park, New York, USA.
Roberta M diFlorio-AlexanderDepartment of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Judith A Austin-StrohbehnDepartment of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Thomas S TruglioHeart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Emily P ZeitlerHeart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; The Dartmouth Institute, Lebanon, New Hampshire, USA.
Hemant KulkarniM&H Research, LLC, San Antonio, Texas, USA.
Amit P AminInterventional Cardiology, Rush University Medical Center, Chicago, Illinois, USA.
Cynthia C TaubDepartment of Medicine, Upstate Medical University, Syracuse, New York, USA. Electronic address: taubc@upstate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a critical need for improved primary prevention of major adverse cardiovascular events (MACE) among women. Breast artery calcification (BAC) can be detected on routine screening mammograms, which are recommended for women aged 40 to 74 years. It is not known if BAC predicts long-term MACE over 10 years in this group.

objectivesThe objectives of the study were to determine the association of BAC with MACE over 10 years of follow-up among women age 40 to 75 years and to assess BAC and a risk modifier for primary prevention.

methodsWe performed a retrospective cohort study of consecutive women aged 40 to 75 without coronary artery disease who underwent a routine screening mammogram at Dartmouth Health from 2011 to 2012, and followed them for development of MACE over 10 years.

resultsAmong 1,216 women, 232 (19%) had BAC. Over 10 years of follow-up, 21% of women with BAC developed MACE compared to 11% women without BAC (P < 0.001). Among women with low (<5%) risk of MACE by pooled cohort equations, those with BAC had an 18% incidence of MACE, compared to 7% in women without BAC (OR: 2.8; 95% CI: 1.5-5.0; P = 0.001).

conclusionsThe use of the pooled cohort equations to risk stratify women for MACE underestimates risk in women with a low predicted risk. BAC is independently associated with an increased risk of MACE and may be useful as an incremental risk modifier.

Indexed as

breast artery calcification (BAC)major adverse cardiovascular events (MACE)pooled cohort equation (PCE)primary preventionWomen’s heart health

Identifiers

PMID42059844
PMCPMC13309335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.