Evidence map›Paper›PMID 42059814›Full record

ArticleMicrobiology spectrum2026

Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in

Lucas Mora-Quilis, Rafael Sanjuán, Pilar Domingo-Calap

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lucas Mora-QuilisInstitute for Integrative Systems Biology, University of Valencia-CSIC, Paterna, Spain.ORCID 0000-0001-9933-9861
Rafael SanjuánInstitute for Integrative Systems Biology, University of Valencia-CSIC, Paterna, Spain.ORCID 0000-0002-1844-545X
Pilar Domingo-CalapInstitute for Integrative Systems Biology, University of Valencia-CSIC, Paterna, Spain.ORCID 0000-0003-2829-8809

Funding

Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana SEJIGENT/2021/014Ministerio de Ciencia, Innovación y Universidades FPU19/04611Ministerio de Ciencia, Innovación y Universidades PID2020-112835RA-I00, PID2023-150309OB-I00, RYC2019-028015-I
6 · The paper itself

Abstract

The emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, which are often more diverse than those represented by clonal isolates. In this study, we investigated how phenotypic diversity within phage-resistant

Indexed as

BacteriophagesKlebsiella InfectionsKlebsiella pneumoniaeBacterial CapsulesHost TropismMutationPhage TherapyPhenotypecapsule reversionKlebsiella pneumoniaephage cocktailphage resistancephenotypic heterogeneity

Identifiers

PMID42059814
PMCPMC13228050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.