Evidence map›Paper›PMID 42059661›Full record

ArticlemBio2026

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis.

Joseph F Carr, Carolina Basurto De Santiago, Shivani A Bhut, Daniel J Warzecha, Sarah A Vastani, Robert Wei, Carmen M Herrera, M Stephen Trent, Beiyan Nan, Angela M Mitchell

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Joseph F CarrDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0001-9228-8168
Carolina Basurto De Santiago *Department of Biology, Texas A&M University, College Station, Texas, USA.
Shivani A Bhut *Department of Biology, Texas A&M University, College Station, Texas, USA.
Daniel J Warzecha *Department of Biology, Texas A&M University, College Station, Texas, USA.
Sarah A VastaniDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Robert WeiDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Carmen M HerreraDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
M Stephen TrentDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-6134-1800
Beiyan NanDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-0326-9529
Angela M MitchellDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0003-1062-0716

Funding

Biogenesis of cyclic and phospholipid-linked enterobacterial common antigenR01AI155915 · NIAID · TEXAS A&M UNIVERSITY · PI MITCHELL, ANGELA MARIE · 2021 to 2025
$2.0M
The Origin of Rod Shape in BacteriaR01GM129000 · NIGMS · TEXAS A&M UNIVERSITY · PI NAN, BEIYAN · 2018 to 2022
$1.6M
LINE1-ORF0 in SLE pathogenesisR21AI176766 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ANDRADE, FELIPE · 2023 to 2024
$450k
National Institute of Allergy and Infectious Diseases R01-AI176766NIAID NIH HHS R01 AI155915NIAID NIH HHS R21 AI176766NIGMS NIH HHS R01 GM129000NIGMS NIH HHS R01-GM129000
6 · The paper itself

Abstract

In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane protein in

Indexed as

Cell MembraneCell WallEscherichia coli K12Escherichia coli ProteinsMembrane ProteinsPeptidoglycanUridine Diphosphate N-Acetylmuramic AcidEscherichia coli ProteinsMembrane Proteinsmuramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenolPeptidoglycanUridine Diphosphate N-Acetylmuramic Acidcell divisiondividosomegram negative cell envelopeouter membranepeptidoglycan synthesisstress response

Identifiers

PMID42059661
PMCPMC13251401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.