Evidence map›Paper›PMID 42059647›Full record

ArticleMicrobiology spectrum2026

Integrated multi-omics analysis reveals gut dysbiosis and altered energy metabolism in Chinese ALS patients.

Xueli Ma, Zewei Jiang, Tianhua Yang, Hao Zhang, Wei Lu, Kuai Liu, Xinfeng Fan, Gaoyi Yang, Shenghai Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xueli Ma *Department of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.
Zewei Jiang *Department of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.
Tianhua Yang *The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Hao ZhangDepartment of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.
Wei LuDepartment of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.ORCID 0009-0006-8953-9572
Kuai LiuDepartment of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.
Xinfeng FanDepartment of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.
Gaoyi YangThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Shenghai WuDepartment of Laboratory, Hangzhou Geriatric Hospital, Hangzhou, China.ORCID 0000-0002-9923-1014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a complex etiology. Emerging evidence implicates gut microbiota dysbiosis in ALS pathology via the gut-brain axis, yet the specific integrative profile of the gut microbiome, virome, and metabolome, particularly in Chinese patients, remains incompletely characterized. Although global diversity indices showed no significant differences, taxonomic analysis revealed distinct compositional shifts. The ALS microbiome was characterized by a significant depletion of beneficial anti-inflammatory genera, specifically

Indexed as

Amyotrophic Lateral SclerosisDysbiosisEnergy MetabolismGastrointestinal MicrobiomeBacteriaChinaEast Asian PeopleFecesFemaleHumansMaleMetabolomeMetabolomicsMiddle AgedMultiomicsOxidative Stressamyotrophic lateral sclerosisgut-brain axisgut microbiomemetabolomicsoxidative stress

Identifiers

PMID42059647
PMCPMC13227962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.