ArticleMicrobiology spectrum2026
Combinatorial effects of a novel SHV-248 variant, NDM-5, and
Chuwen Zhao, Yuxuan Liu, Hanxu Hong, Yun Cao, Xinyue Dai, Qianbin Dai, DanDan Wei, Yang Liu
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Chuwen ZhaoDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0009-0004-5687-8258 Yuxuan LiuDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Hanxu HongDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0009-0005-0937-429X Yun CaoDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xinyue DaiDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Qianbin DaiDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0009-0003-0780-9304 DanDan WeiDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yang LiuDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Funding
Nanchang University YFYLCYJPY202201National Natural Science Foundation of China 32370195National Natural Science Foundation of China 82102411National Natural Science Foundation of China 82260403Natural Science Foundation of Jiangxi Province 20252BAC200545, 20252BAC240499, 20252BAC220054
6 · The paper itselfAbstract
Cefiderocol holds significant therapeutic value against metallo-β-lactamase-producing Enterobacterales. However, reduced susceptibility to cefiderocol in NDM-producing strains is increasingly observed. This study elucidated the mechanism of high-level cefiderocol resistance in a clinical
Indexed as
beta Lactam Antibioticsbeta-LactamasesCefiderocolKlebsiella pneumoniaePorinsBacterial ProteinsDrug Resistance, Multiple, BacterialHumansKlebsiella InfectionsMicrobial Sensitivity TestsBacterial Proteinsbeta Lactam Antibioticsbeta-LactamasesCefiderocolOmpK35 porin, Klebsiella pneumoniaeOmpK36 protein, Klebsiella pneumoniaePorinsblaSHV-248carbapenem-resistantcefiderocolKlebsiella pneumoniaemetallo-β-lactamaseporin deficiencyresistance mechanism
Identifiers
PMID42059619
PMCPMC13228031
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