ArticleJournal of neurochemistry2026
Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.
Article in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hydroxytyrosol as a Multitarget Neuroprotective Agent: Molecular Mechanisms, Pharmacokinetics and Therapeutic Potential in Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2026Review
- Olive Oil as a Modulator of Gut Microbiota and Intestinal Health: A Narrative Review from Microbial Metabolism to Host Responses.Nutrients · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
Hydroxytyrosol (HTyr), a phenolic compound present in olive oil, exhibits antioxidant, anti-inflammatory, and neuroprotective properties, benefiting several age-related diseases. Our previous research demonstrated that oral HTyr administration counteracts age-associated neurogenesis decline in the dentate gyrus of the hippocampus by promoting the production of stem/progenitor cells and new neurons. Since new neurons generated in the dorsal dentate gyrus support contextual memory discrimination, while those generated in the ventral region modulate anxiety, we investigated whether pure HTyr, synthesized in our laboratories, selectively stimulates neurogenesis in these regions in aging mice and evaluated its effects on contextual memory and stress response. Furthermore, we examined its influence on gut microbiota composition, given the well-established role of the microbiota-gut-brain axis in memory and stress regulation. We found that HTyr induced the production of new neurons and neuroblasts in both dentate gyrus regions, with a prevalent effect in the ventral region. Consistently, we observed that HTyr treatment did not improve the contextual memory discrimination but reduced fear sensitization and anxiety-like behavior after a traumatic experience. Furthermore, we observed a reduction of neuroinflammation in HTyr-treated dentate gyri. In parallel, treatment with HTyr preserved the stability of key microbial families linked to intestinal well-being, counteracting the unhealthy effects of stress on gut microbial structure. Our results suggest that HTyr treatment in aging mice enhances resilience to posttraumatic stress by increasing neurogenesis and modulating the microbiota-gut-brain axis. Future studies should explore its potential as a therapeutic intervention for individuals experiencing posttraumatic stress disorder symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.