Evidence map›Paper›PMID 42059559›Full record

ArticleInfection and immunity2026

Lysosomal permeabilization by Group A

Ava Quezada, Kevin Lord, Cheldon Alcantara, Claire Delahunty, Kevin Kim, Olivia Okamoto, John R Yates, Cheryl Y M Okumura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ava QuezadaBiology Department, Occidental College, Los Angeles, California, USA.
Kevin LordBiology Department, Occidental College, Los Angeles, California, USA.ORCID 0009-0002-7858-3624
Cheldon AlcantaraBiology Department, Occidental College, Los Angeles, California, USA.
Claire DelahuntyDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California, USA.ORCID 0009-0001-5328-0806
Kevin KimBiology Department, Occidental College, Los Angeles, California, USA.
Olivia OkamotoBiology Department, Occidental College, Los Angeles, California, USA.ORCID 0009-0007-7301-9262
John R YatesDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0001-5267-1672
Cheryl Y M OkumuraBiology Department, Occidental College, Los Angeles, California, USA.ORCID 0000-0001-9746-6410

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ERIC P ZORRILLA · 2003 to 2026
$46.3M
Macrophage Second-line Responses to Group A Streptoccocus InfectionR15AI176429 · NIAID · OCCIDENTAL COLLEGE · PI OKUMURA, CHERYL YM · 2024 to 2024
$398k
American Heart Association 17GRNT33410851National Science Foundation 2030763NIH HHS 2P41GM103533NIH HHS P60AA006420NIH HHS R15AI176429
6 · The paper itself

Abstract

The human-specific bacterial pathogen Group A

Indexed as

Bacterial ProteinsCytosolLysosomesMacrophagesStreptococcal InfectionsStreptococcus pyogenesAnimalsAntigens, BacterialHumansInterleukin-1betaMicePhagosomesStreptolysinsAntigens, BacterialBacterial ProteinsInterleukin-1betastreptolysin OStreptolysinsGroup A StreptococcushistonesIL-1βinflammasomelysosomemacrophagestreptolysin O (SLO)

Identifiers

PMID42059559
PMCPMC13248697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.