Evidence map›Paper›PMID 42059427›Full record

Trial reportAnnals of medicine2026

Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway.

Yanyan Lin, Yaling Wang, Wanjing Wang, Zhili Deng, Yiya Zhang, Yiran Peng, Jin Tang, Ji Li, Chuchu Huang, Dan Jian

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanyan LinDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Yaling WangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Wanjing WangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Zhili DengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Yiya ZhangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Yiran PengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Jin TangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Ji LiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Chuchu HuangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Dan JianDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5879-2598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to investigate whether TXA protects human dermal fibroblasts from D-galactose-induced senescence

methodsFifty women with melasma were randomized to 3% TXA serum plus moisturizer or moisturizer alone for 8 weeks, with follow-up to week 12. Periorbital wrinkles were graded using a modified Fitzpatrick Wrinkle Scale (MFWS). Separately, D-gal-induced senescence in HDFs was assessed

resultsTopical TXA produced significantly greater MFWS reductions versus moisturizer alone at weeks 4, 8, and 12, with benefit persisting post-treatment. In HDFs, TXA preserved viability, reduced SA-β-gal positivity, attenuated p21/p16, restored Lamin B1, decreased ROS, and rescued antioxidant activities. TXA downregulated IL-6, IL-8, MMP1, and MMP3, and suppressed D-gal-induced ERK, JNK, and p38 phosphorylation. These effects were weakened by G15 or GPR30 knockdown; docking supported a stable TXA-GPR30 interaction.

conclusionsTXA showed clinical anti-wrinkle activity in melasma patients and protected HDFs from D-gal-induced senescence, partly

Indexed as

Cellular SenescenceFibroblastsMAP Kinase Signaling SystemReceptors, G-Protein-CoupledSkin AgingTranexamic AcidAdultCells, CulturedDermisFemaleGalactoseHumansMiddle AgedOxidative StressReactive Oxygen SpeciesReceptors, EstrogenGalactoseGPER1 protein, humanReactive Oxygen SpeciesReceptors, EstrogenReceptors, G-Protein-CoupledTranexamic Acidcellular senescenceGPR30MAPKoxidative stressskin ageingTranexamic acid

Identifiers

PMID42059427
PMCPMC13134749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.