Evidence map›Paper›PMID 42059407›Full record

ReviewPaediatric anaesthesia2026

Error Traps in Pediatric Neuromuscular Block.

Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D de Boer, Ricardo Vieira Carlos

Abstract readReview
In one paragraph

Review in Paediatric anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel Soares de SousaDiscipline of Anesthesiology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5068-1647
Debra FaulkDepartment of Anesthesiology, University of Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0001-8291-6239
Vinicius Caldeira QuintaoDiscipline of Anesthesiology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6459-7983
Niekoo AbbasianDepartment of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0001-5708-6026
Hans D de BoerInternational Network to Improve Perioperative Care (INIPC) Academy, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-0490-2074
Ricardo Vieira CarlosDiscipline of Anesthesiology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5787-8979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological variability and limited physiological reserve.

aimsTo describe common and preventable "error traps" in pediatric neuromuscular block management and to highlight strategies to improve safety across the perioperative continuum.

methodsThis narrative review synthesizes current evidence and clinical practice patterns to identify recurrent pitfalls in the use, monitoring, reversal, and postoperative management of neuromuscular blocking agents in children.

resultsFour major error traps were identified: omission of neuromuscular blocking agents when optimal intubating conditions are required; failure to use quantitative neuromuscular monitoring; inappropriate or mistimed pharmacological reversal; and failure to recognize and treat residual paralysis. These errors contribute to a persistently high incidence of residual neuromuscular block and are associated with increased risk of postoperative respiratory complications. Developmental pharmacokinetic and pharmacodynamic variability further amplifies these risks in pediatric populations.

conclusionsAvoidance of these error traps requires systematic application of evidence-based practices, including routine use of quantitative neuromuscular monitoring and objective confirmation of recovery with a train-of-four ratio ≥ 0.9 prior to extubation. Embedding these principles into clinical practice is essential to improving safety in pediatric anesthesia.

Indexed as

Medication ErrorsNeuromuscular BlockadeNeuromuscular Blocking AgentsChildChild, PreschoolHumansInfantInfant, NewbornNeuromuscular MonitoringPediatric AnesthesiaNeuromuscular Blocking Agentsneostigmineneuromuscular blocking agentsneuromuscular monitoringpediatric anesthesiasugammadex

Identifiers

PMID42059407
PMCPMC13341026

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.