Evidence map›Paper›PMID 42059379›Full record

ArticleAntimicrobial agents and chemotherapy2026

Triclabendazole disrupts mitochondrial electron transport

Tobias Kämpfer, María Eugenia Ancarola, Pascal Zumstein, Alice Bernal, Trix Zumkehr, Seraina Mühlemann, Natalie Wiedemar, Britta Lundström-Stadelmann

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tobias KämpferDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0000-0003-4224-660X
María Eugenia AncarolaDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0000-0001-6971-7147
Pascal ZumsteinDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0000-0002-5360-1614
Alice BernalDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0009-0007-5772-3460
Trix ZumkehrDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0009-0002-3614-4930
Seraina MühlemannDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.
Natalie WiedemarDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0000-0001-9470-4284
Britta Lundström-StadelmannDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.ORCID 0000-0003-2672-5766

Funding

Gottfried und Julia Bangerter-Rhyner-StiftungSwiss National Science Foundation 310030_192072Swiss National Science Foundation 320030-236056Swiss National Science Foundation PZ00P3_216088Uniscientia Foundation
6 · The paper itself

Abstract

Mitochondrial respiration, which relies on succinate dehydrogenase (SDH), among other factors, is essential for cellular energy metabolism. This study shows that triclabendazole and its primary metabolites inhibit SDH in mitochondria of the cestode

Indexed as

AnthelminticsBenzimidazolesEchinococcus multilocularisMitochondriaTriclabendazoleAnimalsElectron TransportHumansSuccinate DehydrogenaseAnthelminticsBenzimidazolesSuccinate DehydrogenaseTriclabendazoleanthelminticbenzimidazolecomplex IIEchinococcushelminthparasitesuccinate dehydrogenasetriclabendazole

Identifiers

PMID42059379
PMCPMC13231881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.