Evidence map›Paper›PMID 42059270›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026

Association Between Postoperative NSAID Use and Bleeding Following Transoral Robotic Surgery.

Brayden Seliger, Jacob Beiriger, Milana Berry, Nilam Patel, Richard B Cannon, Marcus M Monroe, Hilary C McCrary

Abstract readMulticenter Study
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brayden SeligerDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Jacob BeirigerDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Milana BerryDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Nilam PatelDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Richard B CannonDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Marcus M MonroeDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Hilary C McCraryDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety and outcomes of NSAID use following transoral robotic surgery (TORS). STUDY

designRetrospective cohort study using propensity score matching.

settingMulti-institutional database (TriNetX).

methodsPatients undergoing TORS were identified using ICD-10 codes. Two propensity-matched cohorts were compared: (1) patients receiving NSAIDs (ketorolac, celecoxib, ibuprofen) within 14 days postsurgery (n = 3639) versus controls (n = 3639) and (2) patients receiving ketorolac day-of-surgery (n = 1901) versus controls (n = 1901). Primary outcome was postoperative hemorrhage. Secondary outcomes included critical care admission, emergency department visit, and feeding device placement within 14 days.

resultsPostoperative bleeding rates were similar between NSAID and control groups (P = .150). Patients treated with NSAIDs had lower rates of critical care admission (P < .001) and feeding tube placement (P < .001). Emergency department visits showed no significant difference (P = .813). Day-of-surgery ketorolac versus control showed no increased bleeding (P = .460). Ketorolac patients demonstrated significantly lower rates of critical care admission (P < .001) and feeding tube placement (P < .001), with no increase in emergency department visits (P = .312).

conclusionNSAID administration following TORS was not associated with increased postoperative hemorrhage. NSAID use was associated with reduced critical care utilization and feeding tube requirements. These findings support the safety of NSAIDs in multimodal analgesia protocols for TORS patients.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalPostoperative HemorrhagePostoperative PainRobotic Surgical ProceduresAgedFemaleHumansKetorolacMaleMiddle AgedPropensity ScoreRetrospective StudiesAnti-Inflammatory Agents, Non-SteroidalKetorolacenhanced recovery after surgeryNSAIDspain managementpostoperative hemorrhagetransoral robotic surgery

Identifiers

PMID42059270
PMCPMC13417960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.