ReviewMolecular medicine reports2026
Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).
Review in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Circadian rhythms are ~24 h endogenous rhythms driven by both central and peripheral clocks, with their core mechanism being a transcription‑translation feedback loop mediated by master clock genes. The present review outlines the organizational features and regulatory mechanisms of uterine circadian rhythms: Clock genes in the endometrium exhibit phasic rhythmic changes, which are lost after decidualization; rhythmic expression of clock genes in the myometrium influences uterine contractions and regulates the timing of labor. Estrogen and progesterone can modulate core clock genes and affect the decidualization process. As a key output hormone of the central clock, melatonin also modulates the uterine environment and influences delivery timing. Circadian rhythm disruption is associated with the development of diseases such as endometriosis, endometrial cancer and menstrual disorders. Finally, limitations of current research and future directions are discussed to inform rhythm assessment and intervention strategies.
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