Evidence map›Paper›PMID 42059120›Full record

ArticleJournal of medicinal chemistry2026

Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity.

Eslam Roshdy, Ahmet Kilic, Muhamad Mustafa, Ismail Celik, Zeynep Betül Sarı, Ender Simsek, Alessio Nocentini, Simone Giovannuzzi, Claudiu T Supuran, Özen Özensoy Güler and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eslam RoshdyDepartment of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.ORCID 0000-0001-6029-6278
Ahmet KilicDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey.
Muhamad MustafaIBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.ORCID 0000-0002-1384-7556
Ismail CelikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey.ORCID 0000-0002-8146-1663
Zeynep Betül SarıDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey.
Ender SimsekDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey.
Alessio NocentiniDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.ORCID 0000-0003-3342-702X
Simone GiovannuzziDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.ORCID 0000-0002-0669-7481
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.ORCID 0000-0003-4262-0323
Özen Özensoy GülerDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey.
Jean-Yves WinumIBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.ORCID 0000-0003-3197-3414
Manabu AbeDepartment of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.ORCID 0000-0002-2013-4394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrase hCA IX and hCA XII are cancer-associated enzymes involved in tumor pH regulation, hypoxia-driven survival, and therapeutic resistance. Here, we report the rational design, synthesis, and biological evaluation of bis-triazole-linked benzenesulfonamides as novel carbonic anhydrase inhibitors. Several compounds exhibited potent and selective inhibition of hCA IX/XII, with compounds

Indexed as

Antineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesDrug DesignSulfonamidesTriazolesAntigens, NeoplasmBenzenesulfonamidesCell Line, TumorCell ProliferationHumansModels, MolecularStructure-Activity RelationshipAntigens, NeoplasmAntineoplastic AgentsBenzenesulfonamidesCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIISulfonamidesTriazoles

Identifiers

PMID42059120
PMCPMC13181780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.