ArticleChemPlusChem2026
Cyrene Dimethyl Acetal: Potential Alternative Solvent for Pd-Catalyzed Homogeneous Aminocarbonylation of Iodo(hetero)arene Compounds.
Article in ChemPlusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Two potential biomass-derived Cyrene-based reaction media, i.e., Cyrene dimethyl and diethyl acetals, were synthesized and tested as potential polar aprotic alternatives to fossil-based common N,N-dimethylformamide in aminocarbonylation protocols. New solvents were first characterized by their temperature-dependent physicochemical properties, including vapor pressure, density, viscosity, heat capacity, and surface tension. Based on their characteristics, Cyrene dimethyl acetal (CyDiOMe) was selected and used in the Pd-catalyzed aminocarbonylation of iodobenzene and morpholine as a model reaction for optimization. Under optimized conditions, a wide substrate scope was demonstrated for the synthesis of various carboxamides with high conversion (up to 95%) and selectivity in a short reaction time. Twenty-nine products were isolated, proving the applicability of CyDiOMe in Pd-catalyzed aminocarbonylation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.