ArticleContemporary clinical trials communications2026
Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS): A paired, prospective, non-inferiority trial comparing micro-ultrasound and multiparametric MRI at confirmatory biopsy.
Article in Contemporary clinical trials communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Detection to Surveillance: The Evolving Role of Micro-Ultrasound in Prostate Cancer.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Accurate risk assessment is essential for men on active surveillance (AS) of prostate cancer (PCa). Multiparametric MRI improves detection of clinically significant PCa (csPCa; Grade Group ≥2) but is limited by registration error, contraindications and long wait times. Micro-ultrasound (microUS) is a high-resolution, real-time imaging modality that has been shown to be non-inferior to MRI for the detection of csPCa in biopsy-naïve men. However, trials comparing microUS against MRI in men managed by AS remain limited. Methods: MUSIC-AS is a paired, within-subject, prospective non-inferiority diagnostic trial comparing microUS and MRI for the detection of csPCa in men undergoing confirmatory biopsy during AS. Eligible participants include men with previously diagnosed Grade Group 1 PCa requiring confirmatory biopsy. Each participant will undergo pre-biopsy MRI followed by a microUS/MRI-guided biopsy (in which the operator is initially blinded to the MRI during acquisition of microUS targeted cores) followed by MRI targeted cores and systematic sampling. The primary endpoint is the detection of csPCa by combined targeted plus systematic biopsies. The planned sample size is 210 participants. Results: The primary hypothesis is non-inferiority of the csPCa detection rate between microUS-targeted plus systematic biopsies and MRI-targeted plus systematic biopsies. Secondary analyses will evaluate upgrade-free probabilities at 2, 5, and 10 years after confirmatory biopsy. An exploratory analysis using germline sequencing will be performed. Conclusions: MUSIC-AS will determine whether micro-ultrasound is non-inferior to MRI for detecting csPCa in men on active surveillance. Confirmation of non-inferiority may support microUS as a cost-effective, time-efficient, and widely accessible imaging alternative in this population.
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