ArticleiScience2026
Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- CREB promotes starvation-induced sleep loss by regulating octopamine production in Drosophila.Biology open · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Octopamine signaling regulates the intracellular pattern of the presynaptic active zone scaffold within Drosophila mushroom body neurons.PLoS biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Sleep is a widespread yet incompletely understood phenomenon, and animals exhibit diverse arousal states beyond the simple binary of sleep and wake. Essential behaviors such as feeding, courtship, and escape often compete with sleep, and biogenic amines-including dopamine, norepinephrine, and serotonin-help regulate these behavioral states across species. Here, we leverage the small number and well-defined connectivity of neuromodulatory neurons in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.