Evidence map›Paper›PMID 42058905›Full record

ArticleiScience2026

Characterization of retrocopies in 663 individuals with esophageal squamous cell carcinoma.

Xuehan Zhuang, Jianhong Lian, Yong Zhou, Heyang Cui, Jingyun Tan, Wei Mao, Longlong Wang, Shubin Wang, Yongping Cui, Weimin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuehan ZhuangCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Jianhong LianDepartment of Thoracic Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030013, China.
Yong ZhouCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Heyang CuiCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Jingyun TanCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Wei MaoCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Longlong WangCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Shubin WangCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Yongping CuiCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Weimin ZhangCancer Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Department of Oncology, Peking University Shenzhen Hospital; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with partially known etiology. Previous studies have proved the essential role of structural variations (SVs) in ESCC; however, the contribution of retrocopies, a rare form of SV mediated by the L1 retrotransposition and often neglected by the routine SV pipeline, remains unclear. In this study, we applied multi-omics data of 663 pairs of ESCC tumor-normal samples to generate a comprehensive spectrum of retrocopies on ESCC. Generally, worse overall survival of patients who carried retrocopies involving cancer-associated genes suggested a role of retrocopies in ESCC. The enrichment of parent genes in ribosome biogenesis and mitochondrial respiration chain suggested a potential role in energetic modulation. Additionally, the characterization of insertion sites revealed the regulatory function of retrocopies in ESCC. Overall, this study suggests the need to characterize retrocopies in cancer studies, and the comprehensive landscape of retrocopies extends the current understanding of ESCC etiology.

Indexed as

CancerMolecular biology

Identifiers

PMID42058905
PMCPMC13122676

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.