Infectious bursal disease virus suppresses humoral immunity via blocking antibody affinity maturation in chickens.

Yuxin Guo, Zhaocan Zhou, Huixuan Jiao, Li Gao, Xiaoqi Li, Hong Cao, Yongqiang Wang, Shijun J Zheng

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Yuxin GuoState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Zhaocan ZhouState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Huixuan JiaoState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Li GaoState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Xiaoqi LiState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Hong CaoState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Yongqiang WangState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Shijun J ZhengState Key Laboratory of Veterinary Public Health and Security, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blockade of antibody affinity maturation causes vaccination failure, yet whether pathogens exploit this process for immunosuppression remains poorly understood. Infectious bursal disease virus (IBDV) causes immunosuppression in chickens, but its underlying mechanism remains unclear. We show that the anti-IBDV VP2 affinity constant (Ka) remained unchanged between primary and secondary responses, indicating antibody affinity maturation failure. In contrast, anti-NDV F protein antibodies exhibited a >4-fold Ka increase upon secondary response, but this increase was abolished by IBDV coinfection. Consistently, anti-NDV HI titers were reduced in NDV and IBDV-coinfected chickens. IBDV infection decreased splenic IgM

Indexed as

ImmunologyPoultry medicineVirology

Identifiers

PMID42058901

DOI10.1016/j.isci.2026.115596

PMCPMC13122195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.