Evidence map›Paper›PMID 42058900›Full record

ArticleiScience2026

Neuronal Igfbp2 deficiency in the prefrontal cortex impairs cognition through synaptic dysfunction in male mice.

Weiming Zhao, Yanan Gao, Yichan Wang, Ke Peng, Shaoyong Song, Yufan Yang, Baojian Zhao, Xisheng Shan, Li Deng, Ruixia Weng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weiming ZhaoDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yanan GaoDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yichan WangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ke PengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Shaoyong SongDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yufan YangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Baojian ZhaoDepartment of Anesthesiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Xisheng ShanDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li DengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ruixia WengDepartment of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Hong LiuDepartment of Anesthesiology and Pain Medicine, University of California Davis Health System, Sacramento, CA 95817, USA.
Xiaowen MengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Huayue LiuDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Fuhai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin-like growth factor binding protein 2 (Igfbp2) is known to participate in brain development and synaptic regulation, but its specific contribution to prefrontal cortex (PFC)-dependent cognitive function remains unclear. Here, we demonstrate that neuronal Igfbp2 in the PFC plays a critical role in maintaining cognitive performance and synaptic integrity. Neuron-specific Igfbp2 knockdown impaired recognition and spatial memory without altering emotional or locomotor behaviors. Mechanistically, loss of Igfbp2 reduced dendritic spine density, downregulated synapsin-1 and PSD-95 expression, and weakened excitatory synaptic transmission. Remarkably, the local infusion of recombinant Igfbp2 protein restored synaptic architecture and rescued cognitive deficits. Together, these findings identify neuronal Igfbp2 as an essential regulator of PFC-dependent cognition and highlight its potential as a therapeutic target for cognitive dysfunction.

Indexed as

biochemistryCell biologyneuroscience

Identifiers

PMID42058900
PMCPMC13122697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.