Evidence map›Paper›PMID 42058883›Full record

ArticlePNAS nexus2026

Detecting and forecasting tipping points from sample variance alone.

Naoki Masuda

Abstract read
In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Naoki MasudaGilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-1567-801X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticipating tipping points in complex systems is a fundamental challenge across domains. Traditional early warning signals (EWSs) based on critical slowing down, such as increasing sample variance, are widely used, but their ability to reliably indicate imminent bifurcations and forecast their timing remains limited. Here, we introduce TIPMOC (TIpping via Power-law fits and MOdel Comparison), a parametric framework designed to statistically detect the approach of a bifurcation and estimate its future location using only the sample variance. TIPMOC exploits the mathematical property that variance diverges with a characteristic power-law form near codimension-one bifurcations. By sequentially monitoring system variance as a control parameter changes, TIPMOC statistically adjudicates between linear and power-law divergence at each step. When evidence favors power-law divergence, TIPMOC forecasts the impending tipping point and estimates its position; otherwise, it avoids false positives. Through numerical simulations, we demonstrate TIPMOC's robustness and accuracy in both detection and timing prediction across different types of dynamics and bifurcation, whereas the accuracy of timing prediction is limited. TIPMOC shows low false positive rates and performs well even with uneven sampling and colored noise. This method thus enhances the interpretability and practical utility of classical EWSs, serving as both a transparent add-on and a stand-alone statistical tool for forecasting regime shifts in diverse complex systems.

Identifiers

PMID42058883
PMCPMC13123519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.