Evidence map›Paper›PMID 42058880›Full record

ArticleResuscitation plus2026

Wolf Creek XVIII Part 6: transforming clinical trial design in cardiac arrest research.

Karen G Hirsch, Janet Bray, Clifton W Callaway, Keith Couper, Ian R Drennan, Theresa Olasveengen, Gavin D Perkins, Jonathan Elmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karen G HirschDepartment of Neurology, Stanford University, Palo Alto, CA, USA.
Janet BraySchool of Public Health and Preventive Medicine, Monash University, Victoria and Curtin School of Nursing, Curtin University, Western Australia, Australia.
Clifton W CallawayDepartment of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Keith CouperWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Ian R DrennanDivision of Emergency Medicine and Institute of Health Policy, Management, and Evaluation, Ornge Critical Care Transport, University of Toronto, Toronto, ON, Canada.
Theresa OlasveengenDepartment of Anesthesia and Intensive Care Medicine, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Norway.
Gavin D PerkinsWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Jonathan ElmerDepartments of Emergency Medicine, Critical Care Medicine and Neurology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 50th Anniversary Wolf Creek XVIII Conference was hosted by the Max Harry Weil Institute for Critical Care Research and Innovation in Ann Arbor, Michigan, USA on June 19-21, 2025. "Transforming Clinical Trial Design in Cardiac Arrest Research" was a topic of focused presentation and discussion. Participants included invited panelists and conference attendees made up of international academic and industry scientists as well as thought leaders in the field of cardiac arrest resuscitation. Panelists identified six key opportunities to transform clinical trial design: (1) Selecting the "right" patient and intervention, (2) Optimizing randomization, (3) Measuring relevant and unbiased outcomes, (4) Designing alternative approaches to "usual" randomize controlled trials (RCTs), (5) Maintaining public trust and engagement, and (6) Changing the approach to knowledge translation from research into clinical practice.

Indexed as

Cardiac arrestClinical trialsResearch

Identifiers

PMID42058880
PMCPMC13123617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.