Evidence map›Paper›PMID 42058833›Full record

Observational studyResearch and practice in thrombosis and haemostasis2026

Patterns of presentation of suspected and confirmed recurrent venous thromboembolism in patients with prior venous thromboembolism.

Vicky Mai, Emily S L Martens, Marc Righini, Sam Schulman, Venkatesh Thiruganasambandamoorthy, Veronica Bates, Amanda Pecarskie, Michael J Kovacs, Shaun Visser, Sudeep Shivakumar and 11 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02297373 (Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02297373 completednot on this map

Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis

TypeobservationalSponsorOttawa Hospital Research InstituteRan2014 to 2019Enrolled744ConditionsThromboembolic Disease Recurrent, Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vicky MaiCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada.
Emily S L MartensDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Marc RighiniDivision of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Sam SchulmanDepartment of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Venkatesh ThiruganasambandamoorthyUniversity of Ottawa, Department of Emergency Medicine, Ottawa, Ontario, Canada.
Veronica BatesDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Amanda PecarskieDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Michael J KovacsDivision of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.
Shaun VisserDepartment of Emergency Medicine, Hôpital Montfort, Ottawa, Ontario, Canada.
Sudeep ShivakumarDepartment of Medicine, Dalhousie University, Nova Scotia Health, Halifax, Nova Scotia, Canada.
Melanie TanHospital Gelderse Vallei, Ede, the Netherlands.
Marc RodgerDepartment of Medicine, McGill University, McGill University Health Center, Montreal, Québec, Canada.
Dimitrios ScarvelisDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Aurélien DellucDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Philippe GirardDépartement de Pneumologie, Institut Mutualiste Montsouris, Paris, France.
Menno V HuismanDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Philip S WellsDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Frederikus A KlokDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Grégoire Le GalDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Susan R KahnDivision of Internal Medicine, Department of Medicine, McGill University, Montreal, Québec, Canada.
PREDICTORS study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with prior venous thromboembolism (VTE) seem to recur more frequently at the same site as their prior VTE, but their symptoms at presentation of suspected recurrent VTE is unclear. Objectives: The aim was to describe the patterns of presentation of suspected and confirmed recurrent VTE. Methods: This is a secondary analysis of the PREDICTORS study (ClinicalTrials.gov: NCT02297373), an international prospective multicenter observational cohort study. The primary outcomes were the location of symptoms and confirmed diagnosis of suspected recurrent VTE. Results: In total, 708 patients were included. Patients with isolated deep venous thrombosis (DVT) as the most recent prior VTE presenting with suspected recurrent VTE had more frequently lower extremity symptoms only (249/343; 73%), rather than respiratory symptoms only (41/343; 12%), and confirmed recurrent VTE were mostly isolated proximal DVT (78/100; 78%). Patients with isolated pulmonary embolism as the most recent prior VTE presented more frequently with respiratory symptoms only (136/237; 56%), rather than lower extremity symptoms only (42/237; 18%), and confirmed recurrent VTE were more frequently isolated pulmonary embolism (38/62; 61%). Among patients with DVT as the most recent prior VTE, confirmed recurrent DVT were more frequently in the ipsilateral leg of the index event (ipsilateral 72/468 [15%], contralateral 31/468 [7%]; odds ratio 2.3 [95% CI, 1.5-3.6]). Conclusion: In addition to confirming that patients were more frequently diagnosed with recurrent VTE at the same site of their last VTE, our study reported on suspected recurrent VTE symptoms and showed that patients presented more frequently with symptoms related to the same site of their last VTE.

Indexed as

Venous ThromboembolismAdultAgedFemaleHumansLower ExtremityMaleMiddle AgedProspective StudiesPulmonary EmbolismRecurrenceRisk FactorsVenous Thrombosisdeep venous thrombosispulmonary embolismrecurrencevenous thromboembolism

Identifiers

PMID42058833
PMCPMC13122812

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.