ReviewWorld journal of methodology2026
Interleukin-1 receptor antagonist autoantibodies in Still's disease: Mechanistic insights and laboratory testing.
Review in World journal of methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 author.
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Abstract
Neutralizing autoantibodies against interleukin-1 receptor antagonist (IL-1RA) have been identified in patients with Still's disease, often in association with hyperphosphorylation of the endogenous soluble IL-1RA protein. Although several cytokines and signaling pathways have been implicated in the pathogenesis of Still's disease, the mechanisms underlying anti-IL-1RA autoantibody production remain unclear. Their detection is challenging due to assay heterogeneity, and therefore, a combination of different detection methods is recommended. This minireview explores potential predisposing factors for IL-1RA autoantibody development and discusses their biological and clinical significance. It also summarizes current diagnostic approaches for their detection, highlighting key challenges, pitfalls, and limitations.
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