ArticleFrontiers in nutrition2026
Relationship between iodine nutritional status and low handgrip strength in a Northwestern Chinese cohort: construction of a predictive nomogram model.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Grip strength is a key marker for sarcopenia screening, yet the influence of iodine nutritional status on low grip strength (LGS) remains poorly understood. Methods: This cross-sectional study analyzed 810 community-dwelling adults in Lanzhou, China, randomly assigned to training ( Results: LGS prevalence was 18.8% in the training cohort. Multivariate analysis showed female sex (OR = 0.34), greater height (OR = 0.94), and excessive iodine (OR = 0.36) were inversely associated with LGS, whereas age (60-74 years: OR = 2.20; ≥75 years: OR = 9.73), smoking (OR = 3.20), and SP (OR = 1.02) correlated with higher LGS odds. The nomogram demonstrated moderate discrimination (AUC: 0.723 training, 0.662 validation) with good calibration (Brier scores: 0.134 training, 0.147 validation; H-L Conclusion: The nomogram provides a practical, objective tool for early identification of individuals at high probability of LGS. Moderate-to-high UIC is associated with LGS odds, particularly in euthyroid adults. This model may guide targeted screening and interventions in community settings. In the cross-sectional design, causal inferences cannot be drawn; Further research is warranted to elucidate these complex relationships.
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