Evidence map›Paper›PMID 42058697›Full record

ArticleJCEM case reports2026

Double filtration plasmapheresis in antithyroid drug-refractory Graves disease with a massive goiter.

Miku Yamazaki, Hiroyuki Uchinuma, Yuka Yokota, Hiroki Ishii, Takeshi Moriguchi, Kyoichiro Tsuchiya

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miku YamazakiDepartment of Diabetes and Endocrinology, University of Yamanashi Hospital, Yamanashi 409-3898, Japan.
Hiroyuki UchinumaDepartment of Diabetes and Endocrinology, University of Yamanashi Hospital, Yamanashi 409-3898, Japan.ORCID https://orcid.org/0009-0002-8540-2801
Yuka YokotaDepartment of Pathology, University of Yamanashi Hospital, Yamanashi 409-3898, Japan.
Hiroki IshiiDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID https://orcid.org/0000-0003-1329-2180
Takeshi MoriguchiDepartment of Emergency and Critical Care Medicine, University of Yamanashi Hospital, Yamanashi 409-3898, Japan.
Kyoichiro TsuchiyaDepartment of Diabetes and Endocrinology, University of Yamanashi Hospital, Yamanashi 409-3898, Japan.ORCID https://orcid.org/0000-0002-2863-4561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of double filtration plasmapheresis (DFPP) performed in medication-resistant Graves disease (GD) with a massive goiter. A 19-year-old female was diagnosed with GD and initially demonstrated poor medication compliance. She presented with loss of consciousness from hypoxemia due to goiter-related tracheal narrowing. Despite inpatient drug therapy, the thyroid hormone levels remained high. We performed DFPP to control thyrotoxicosis before proceeding with thyroidectomy. After 4 sessions, thyroid hormone levels improved, enabling total thyroidectomy. GD with a large goiter may be refractory to medical therapy. In such cases, DFPP can improve thyroid hormone levels.

Indexed as

ATD-resistant thyrotoxicosisDFPPGraves diseaselarge goitertotal thyroidectomy

Identifiers

PMID42058697
PMCPMC13122022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.