Molecular mechanisms underlying psoriasis and depression: an integrated analysis using mendelian randomization, transcriptomics, and single-cell sequencing.

Baojun De, Wenfeng Bao, Nagongbilige Hea, Jun Fang

Abstract read

In one paragraph

Article in Frontiers in molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Baojun DeDepartment of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute, Hohhot, Inner Mongolia, China.

Wenfeng BaoDepartment of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute, Hohhot, Inner Mongolia, China.

Nagongbilige HeaDepartment of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute, Hohhot, Inner Mongolia, China.

Jun FangDepartment of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute, Hohhot, Inner Mongolia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Psoriasis, an immune-mediated systemic inflammatory disease affecting skin, vessels, and joints, often co-occurs with depression. Routine depression screening is vital, as mood disorders link to inflammation, visible lesions, and functional limitations. Methods: The study integrated Mendelian randomization (MR), transcriptomics, and single-cell omics via public databases to explore comorbidity mechanisms. Results: MR identified 340 psoriasis-related and 307 depression-related eQTL-gene associations; 9 intersected. LASSO found 4 key Genes ( Conclusion: These 4 genes mediate comorbidity via inflammation, immune metabolism, and ferroptosis. Folic acid pathways have therapeutic value, laying a foundation for precision therapy.

Indexed as

comorbiditydepressionferroptosisfolic acidimmune cells infiltrationmendelian randomizationmulti-omics integrationpsoriasis

Identifiers

PMID42058679

DOI10.3389/fmmed.2026.1770665

PMCPMC13124126

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