Evidence map›Paper›PMID 42058478›Full record

ArticleFrontiers in pediatrics2026

Contrast enema in suspected post-NEC intestinal strictures without direct stenosis signs: a retrospective study of 191 surgically confirmed cases.

Jinfeng Hou, Yong Qin, Qingshuang Liu, Jinping Hou, Yi Wang, Zhenhua Guo, Wei Liu, Shengde Wu

Abstract read
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In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jinfeng HouDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Yong QinRadiology Department, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Qingshuang LiuDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Jinping HouDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Yi WangDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Zhenhua GuoDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Wei LiuDepartment of General Surgery & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Shengde WuUrology Department, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing Key Laboratory of Pediatrics, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Contrast enema (CE) is widely used for suspected post-NEC intestinal strictures, yet some surgically confirmed strictures show no direct stenosis on CE. We aimed to characterize clinical and CE findings in these cases and identify features associated with multi-segment involvement to inform preoperative management. Methods: We retrospectively reviewed 191 infants with surgically confirmed post-NEC intestinal strictures who underwent preoperative CE. Infants were classified as CE-positive (direct stenosis on CE) or CE-negative (no direct stenosis). Based on intraoperative findings, strictures were further categorized as single-segment or multi-segment. Clinical characteristics and radiographic signs were compared between groups. Results: Of 191 infants, 153 were CE-positive and 38 were CE-negative. CE-negative infants had a higher rate of prematurity (78.95% vs. 52.94%, Conclusion: In surgically confirmed post-NEC strictures without direct stenosis on CE, infants are more often premature with lower birth weight, and lesions tend to involve the ileum and right colon. Indirect CE signs such as small-bowel dilatation and microcolon may support clinical decision-making in CE-negative cases, and bead-like/sausage-like appearance suggests a high likelihood of multi-segment involvement.

Indexed as

contrast enemainfantintestinal stricturenecrotizing enterocolitis (NEC)small bowel obstruction

Identifiers

PMID42058478
PMCPMC13121258

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