ReviewStem cells international2026
Urine-Derived Stem Cells: Applications of Paracrine-Driven Regeneration and Functional Recovery in Multiorgan Systems.
Review in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Urine-Derived Stem Cells: Applications of Paracrine-Driven Regeneration and Functional Recovery in Multiorgan Systems.Stem cells international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self-healing process of the body using stem cells or their derivatives, in which urine-derived stem cells (USCs) stand out as a novel and promising tool in treating various diseases recently. USCs are widely believed to derive primarily from glomerular parietal epithelial cells and podocytes and can be readily isolated from urine. Owing to telomerase-associated self-renewal capacity, USCs proliferate efficiently in vitro, while their outstanding differentiation potential and paracrine effects support promising applications in tissue regeneration and functional recovery. The extracellular particles (EPs) of USCs, including various activity factors, exosomes, and other extracellular vesicles (EVs), play significant roles in the paracrine effects of USCs, which have gained recognition as pivotal factors in the therapeutic studies of USCs. USCs-EPs can affect on diseases in different organ systems through various mechanisms, in which cell differentiation, angiogenesis, and cell proliferation and migration are the three mainly affected functions. And the USCs-EPs may play dual roles based on different curative effects. Besides, the varied modification and encapsulation of USCs-EPs may promote their therapeutic effects. Up to now, USCs-EPs have been widely studied in multiorgan systems and are considered to be superior to USCs because of the rare risks of diverse genetic backgrounds, teratoma formation and immunogenicity. Although in the current preclinical stage, USCs-EPs represent a promising novel tool in stem cell therapy and warrant further exploration for their clinical potential.
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Registered trials
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