Trial reportFrontiers in oral health2026
Efficacy and safety of low-concentration whitestrips for extrinsic tooth discoloration: a randomized controlled trial.
Trial report in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aimed to evaluate the effectiveness of Low-concentration Whitestrips with 3% hydrogen peroxide (HP) on extrinsic discoloration of incisors, and to evaluate the safety of whitening process. Methods: Enrolled adults with extrinsic discolored incisors (Vita shade guide value >1M1.5) were randomized into treatment and control groups. Treatment group used Low-concentration Whitestrips, control group used placebo. Tooth color was assessed at baseline and follow-up visits at Day 1, Day 3 and Day 14. Tooth color was assessed by digital shade meter (primary outcomes), and VITA 3D-Master shade guide (secondary outcomes), respectively. Adverse events (AEs) and serious adverse events (SAEs) including oral and systemic symptoms based on clinical examination and participants' description were also recorded. Results: 70 adults participated. The primary and secondary outcomes objectively and subjectively demonstrated that the treatment group exhibited better whitening effects than the control. Additionally, the treatment group was observed to attain better effects with prolonged use, with W* values based on digital shade meter increasing from 72.86 to 78.73, and the VITA 3D-Master shade guide color values decreasing from 14.91 to 11.23 ( Conclusions: From both objective and subjective perspectives, Low-concentration Whitestrips were found to be effective in extrinsic discoloration tooth bleaching and were well-tolerated by participants. Clinical Trial Registration: Chinese Clinical Trial Registry: https://www.chictr.org.cn/ (ChiCTR2300073971) and National Health Information Platform: http://114.255.48.20/login (MR-51-23-033324).
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