Evidence map›Paper›PMID 42058368›Full record

ArticleNeuroImmune pharmacology and therapeutics2026

HIV-1 Tat expression drives progressive synaptic decline: evidence from longitudinal [

Tara Chand Yadav, Isabella C Orsucci, Spencer V Thompson, Zhanhong Wu, Zibo Li, Hong Yuan, Barkha J Yadav-Samudrala, Sylvia Fitting

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImmune pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tara Chand YadavDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Isabella C OrsucciDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Spencer V ThompsonBiomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhanhong WuDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zibo LiDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Hong YuanDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Barkha J Yadav-SamudralaDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sylvia FittingDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis usersR01DA055523 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sylvia Fitting, Wei Jiang · 2022 to 2026
$3.5M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
NCI NIH HHS P30 CA016086NIDA NIH HHS R01 DA055523NIH HHS S10 OD023611
6 · The paper itself

Abstract

Objectives: In the era of combined antiretroviral therapy (cART), human immunodeficiency virus type 1 (HIV-1) is considered a chronic condition that continues to affect the brain. As synaptodendritic injury occurs early, often years before the onset of clinical symptoms, noninvasive neuroimaging methods such as positron emission tomography (PET) hold promise for early detection. Methods: A doxycycline (DOX)-inducible HIV-1 Tat Results: Longitudinal [ Conclusions: These findings provide

Indexed as

[11C]-UCB-JHIV-1 Tatlongitudinal PET imagingPSD-95SV2Asynaptic density decline

Identifiers

PMID42058368
PMCPMC13123889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.